Lawrence B Afrin Selected Research

Mast Cell Activation Syndrome

5/2022	Evaluation of a tryptase depletion index for better pathologic identification of mast cell activation syndrome.
1/2022	Post-HPV-Vaccination Mast Cell Activation Syndrome: Possible Vaccine-Triggered Escalation of Undiagnosed Pre-Existing Mast Cell Disease?
1/2019	Recognition and Management of Medication Excipient Reactivity in Patients With Mast Cell Activation Syndrome.
8/2017	Successful targeted treatment of mast cell activation syndrome with tofacitinib.
1/2017	Case Report: Treatment of systemic mastocytosis with sunitinib.
12/2015	Successful treatment of mast cell activation syndrome with sunitinib.
10/2013	Utility of hydroxyurea in mast cell activation syndrome.
7/2011	Polycythemia from mast cell activation syndrome: lessons learned.

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Lawrence B Afrin Research Topics

Disease

8	Mast Cell Activation Syndrome 05/2022 - 07/2011
5	Mast Cell Activation Disorders (Mast-Cell Disease) 01/2022 - 07/2011
4	Systemic Mastocytosis 11/2017 - 10/2013
3	Neoplasms (Cancer) 12/2015 - 09/2002
3	Pain (Aches) 12/2014 - 04/2011
2	Hypersensitivity (Allergy) 01/2017 - 12/2015
1	Neuralgia (Stump Neuralgia) 01/2022
1	Sleep Apnea Syndromes (Sleep Apnea) 01/2022
1	COVID-19 11/2021
1	Autonomic Nervous System Diseases (Dysautonomia) 01/2020
1	Hypoxia (Hypoxemia) 01/2020
1	Dyspareunia 07/2019
1	Vaginitis 07/2019
1	Exanthema (Rash) 11/2017
1	Asthenia 11/2017
1	Rheumatoid Arthritis 08/2017
1	Anaphylaxis (Anaphylactic Shock) 11/2015
1	Flushing 11/2015
1	Mastocytosis 11/2015
1	Cytopenia 03/2015
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 03/2015
1	Inflammation (Inflammations) 12/2014
1	Sickle Cell Anemia (Hemoglobin S Disease) 10/2013
1	Agranulocytosis (Granulocytopenia) 01/2012
1	Felty Syndrome (Syndrome, Felty's) 01/2012
1	Large Granular Lymphocytic Leukemia 01/2012
1	Infections 05/2011
1	Burning Mouth Syndrome (Syndrome, Burning Mouth) 04/2011
1	Polyneuropathies (Polyneuropathy) 08/2010
1	Acute Pain 09/2002
1	Inappropriate ADH Syndrome (SIADH) 09/2002

Drug/Important Bio-Agent (IBA)

2	Tryptases (Tryptase)IBA 05/2022 - 11/2015
2	Antidepressive Agents (Antidepressants)IBA 01/2022 - 10/2013
2	Phosphotransferases (Kinase)IBA 11/2017 - 12/2015
2	Imatinib Mesylate (Gleevec)FDA Link 01/2017 - 12/2015
2	Sunitinib (Sutent)FDA Link 01/2017 - 12/2015
2	Hydroxyurea (Hydrea)FDA LinkGeneric 12/2014 - 10/2013
2	Pharmaceutical PreparationsIBA 10/2013 - 01/2012
1	Phenobarbital (Luminal)FDA Link 05/2022
1	VaccinesIBA 01/2022
1	18 16 11 Types 6 Human Papillomavirus Recombinant Vaccine Quadrivalent (Gardasil)FDA Link 01/2022
1	Histamine Antagonists (Antihistamines)IBA 01/2022
1	Hemostatics (Antihemorrhagics)IBA 08/2021
1	isonitrosoacetophenoneIBA 08/2021
1	AnticoagulantsIBA 08/2021
1	Inflammation MediatorsIBA 01/2020
1	Excipients (Suspending Agents)IBA 01/2019
1	masitinibIBA 11/2017
1	tofacitinibIBA 08/2017
1	Tyrosine Kinase InhibitorsIBA 01/2017
1	CytokinesIBA 01/2017
1	Tyrosine (L-Tyrosine)FDA Link 12/2015
1	Histamine (Histamine Dihydrochloride)FDA Link 11/2015
1	ofatumumab FDA Link 03/2015
1	Monoclonal AntibodiesIBA 03/2015
1	Lenalidomide (CC 5013)FDA Link 03/2015
1	A-factor (Streptomyces)IBA 12/2014
1	Anticonvulsants (Antiepileptic Drugs)IBA 10/2013
1	Narcotics (Narcotic Analgesics)IBA 10/2013
1	Ribonucleotide Reductases (Ribonucleotide Reductase)IBA 10/2013
1	Analgesics (Analgesic Drugs)IBA 10/2013
1	Non-Narcotic Analgesics (Analgesics, Non Narcotic)IBA 10/2013
1	Sulfasalazine (Azulfidine)FDA LinkGeneric 01/2012
1	Pentamidine (NebuPent)FDA LinkGeneric 05/2011
1	Cytochrome P-450 CYP2C19IBA 05/2011
1	Cytochrome P-450 CYP2C19 InhibitorsIBA 05/2011
1	ZincIBA 08/2010
1	CopperIBA 08/2010
1	Hydromorphone (Dilaudid)FDA LinkGeneric 09/2002
1	Vasopressins (Vasopressin)IBA 09/2002
1	Fentanyl (Sublimaze)FDA LinkGeneric 09/2002
1	Dexamethasone (Maxidex)FDA LinkGeneric 09/2002
1	SodiumIBA 09/2002

Therapy/Procedure

5	Therapeutics 11/2021 - 04/2011
1	Oral Pathology 04/2011
1	Patient-Controlled Analgesia (Analgesia, Patient Controlled) 09/2002